Pharmaceutical Chemistry

This is an introductory course that addresses selected topics in biology as applied to prokaryotes and eukaryotes. Cell biology, genetics, respiration, photosynthesis, evolution and ecology are discussed. (lec 3, lab 3) cr 3.

This course is a study of higher plants and animals with special emphasis on structure and function. Botanical topics include plant anatomy, reproduction, water relations, mineral nutrition, and control of growth and development. The zoological component includes the anatomy and physiology of animal tissues, organs and systems, and their functional integration. (lec 3, lab 3) cr 3.

This course provides an introduction to the fundamental principles of chemistry. Topics include atomic and molecular structure, nuclear chemistry, stoichiometry, the periodic table and periodicity, and the properties of solutions. PREREQ: Grade 12U level chemistry or CHMI 1041 or permission of the department. (lec 3, tut 1, lab 2) cr 3.

This course is a continuation of CHMI 1006. Topics include thermochemistry, chemical thermodynamics, kinetics, chemical equilibrium, acid-base chemistry, buffer solutions, electrochemistry and introductory organic chemistry. PREREQ: CHMI 1006 or 1041 (min. 80%). (lec 3, tut 1, lab 3) cr 3.

This is a problem-solving course which includes an extensive treatment of differential calculus and an introduction to integral calculus. Topics include limits, continuity, differentiation, standard functions, Taylor polynomial approximation, indeterminate forms and Hospital's rules, and practical applications. The course concludes with summation, integration, techniques of integration and the calculation of areas and volumes. PREREQ: Grade 12 4U Advanced Functions (minimum 60%), MATH 1912 or equivalent. (lec 3, tut 1) cr 3.

This course begins with further techniques of integration, approximate integration, improper integrals and techniques for solving some simple first-order differential equations. This is followed by parametric and polar curves, and calculations of arc length, surface area and volume. Sequences, series, power series and Taylor series are then introduced. The course concludes with elementary aspects of functions of several variables. PREREQ: MATH 1036. (lec 3, tut 1) cr 3.

This is the first of two courses in introductory physics. The course covers mechanics (dynamics and kinematics), vectors and energy, properties of matter, heat and thermodynamics, and waves. Throughout this course, examples will be chosen from both the physical and the life sciences. (lec 3, tut 1, lab 3) cr 3. Students may not retain credit for both PHYS 1006 and PHYS 1206.

This is the second of two courses in introductory physics. The course covers geometrical optics, electricity and magnetism, and modern physics. Throughout this course, examples will be chosen from both the physical and the life sciences. PREREQ: PHYS 1006 or equivalent. (lec 3, tut 1, lab 3) cr 3. Students may not retain credit for both PHYS 1007 and PHYS 1207.

This course examines the theory and techniques of classical quantitative analysis, including gravimetry and precipitation titrations, volumetric analysis, oxidation-reduction titrations, complexometric titrations, as well as the treatment of data. Introductory notions of instrumental techniques are presented. PREREQ: CHMI 1006/7. Students registered in the specialized program in Chemistry with an average of at least 80% in CHMI 1006 may take CHMI 2117 in lieu of CHMI 1007. (lec 3, lab 3) cr 3.

This course introduces the structure and function of proteins and nucleic acids. Topics include protein structure and function, nucleic acid chemistry, DNA and its replication, the genetic code and protein synthesis, regulation of gene expression, cloning and gene isolation, DNA sequencing, and enzyme kinetics. PREREQ: CHMI 2426. (lec 3, lab 3) cr 3.

This course presents an introduction to organic chemistry. Topics include structure and bonding, nomenclature, stereochemistry, and an introduction to the chemistry of a few classes of organic compounds. PREREQ: CHMI 1006/7. (lec 3, lab 3, tut 1) cr 3.

This course includes a detailed investigation of the reactions of hydrocarbons and monofunctional organic compounds. The factors which affect these reactions are also discussed. PREREQ: CHMI 2426. (lec 3, lab 3, tut 1) cr 3.

This course introduces the principles of chemical thermodynamics including the first, second and third laws of thermodynamics and the relations of thermodynamic functions to chemical equilibria in the ideal and nonideal solid, liquid and gaseous states. It includes elementary applications of the phase rule. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2516 and CHMI 2526.

This course introduces the physico-chemical principles of electrochemistry, chemical kinetics, surface and colloid chemistry. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2517 and CHMI 2527.

The organization of data, discrete distributions (binominal, Poisson), continuous distributions (uniform, normal and skewed), and linear combinations of variables are studied. The techniques of hypothesis testing and interval estimation are applied to problems involving means, variances, proportions, frequency tables, regression, and correlation. Students are introduced to the use of statistical computer software. PREREQ: MATH 1036. (lec 3, tut 1) cr 3. Students may only retain credit for one of STAT 2246, STAT 2126, STAT 2066, MATH 2261, MATH 2236, MATH 2246, or ENGR 2017.

The course presents the principles and components of modern instruments currently used in chemical, biological, biochemical and environmental sciences, including forensic and pharmaceutical sciences to measure and characterize elements, ions, small and large molecules and compounds. It covers the main divisions of instrumental anyalysis based on: 1) separation techniques such as gas, liquid and supercritical chromatography, electrophoresis, gel permeation/filtration; 2) spectroscopy, spectrometry and optical phenomena such as ultra-violet, visible, infra-red, luminescence and fluorescence techniques, atomic spectrometry, surface plasmon resonance, X-ray techniques, radioactivity measurements, mass spectrometry; and 3) electrochemical methods based on potentiometry, voltammetry and biosensors. The interfacing of instruments (hyphenated techniques) is also covered and numerous applications are presented. PREREQ: CHMI 2117. (lec 3, lab 3) cr 3.

Topics include: intermediary metabolism of carbohydrates, lipids, and amino acids; regulation of metabolism; membrane structure and functions; transmembrane signalling and photosynthesis. PREREQ: CHMI 2227 & CHMI 2427 or 2425. (lec 3, lab 3) cr 3 Lecture (3.00). Equivalent to CHMI-3226FL, CHMI-3226EA.

This course covers the spectroscopic methods used to determine the structure of organic compounds. The techniques presented include ultraviolet-visible (UV-Vis), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies and mass spectrometry (MS). PREREQ: CHMI 2427. (lec 3, lab 3) cr 3.

Students will study various concepts dealing with how the body interacts with drugs. They will first learn the routes of administration for drugs based on physico-chemical properties. They will then be introduced to the basic concepts of pharmacokinetics, pharmacodynamics and drug distribution, metabolism and elimination. Finally, the mechanism of action of drugs on the central nervous, cardiovascular, renal, gastrointestinal, immune and respiratory systems, and toxicology of drugs will be reviewed. PREREQ: CHMI 3226 and CHMI 3416. (lec 3) cr 3. Lecture (3.00).

Explores the basic concepts of medicinal chemistry. An understanding of structure and stereochemistry and of chirality and drug design is developed. Drug activity is discussed in general terms of structure-activity relationships such as observed in the interaction of enzymes with substrates and inhibitors, and receptors with agonists and antagonists. Selective drugs and their mode of action include sulfa drugs, B-lactam antibiotics, agents to control Parkinson?s disease and anticancer drugs. PREREQ: CHMI 2427 and 2227. (lec 3) cr 3 Lecture (3.00).

This course is designed for students enrolled in a science program to gain practical experience in their field of study. The placement must be approved by the course instructor. (exp 3) 3cr. PREREQ: Having completed at least 60 cr of a Bachelor of Science degree. Students cannot use their NATS 4005 lab experience to satisfy the requirements for NATS 3206.

This course focuses on the description and evaluation of drugs that influence human behaviour. The course emphasizes thebiochemical mechanisms and psychological effects of drugs used within clinical settings, although all major pharmacological classes are covered. PREREQ: NSCI/PSYC 2606 & NSCI/PSYC2617 or dept.'s permission. (lec 3, lab 1) cr 3. Students cannot retain credit for both NSCI 3506 and PSYC 3506.

Examines the biochemical principles and cellular and molecular mechanisms that contribute to the manifestation of toxicity caused by drugs and environmental chemicals with emphasis on potential routes of uptake, the enzymes which catalyze biotransformation of xenobiotics, storage and elimination. The chemical reactivity, enzymatic induction and inhibition, the role of the cytochrome P-450-dependent mixed-function oxidase system in the deactivation and bioactivation of xenobiotics and glutathione conjugation are also presented. Topics include: reproductive toxicology and teratology, developmental toxicology, carcinogenesis, genotoxicity and mutagenesis, immunotoxiocology, neurotoxicology, environmental toxicology, clinical and regulatory toxicology, human health and ecotoxicological risk assessments. Selected classes of compounds and their exposure routes, mechanisms of toxicity, fate, toxicologic sequelae and their antidotes are considered in depth. PREREQ: CHMI 3226. (lec 3) cr 3 Lecture (3.00).

his course will describe how medicinal compounds are discovered from diverse sources. The use of organic chemistry to modify lead compounds will first be studied, with a particular emphasis on the optimization of the molecular structure to overcome undesired pharmacokinetics and pharmacodynamic properties. The students will then be introduced to modern methods of chiral synthesis for the production of enantiomeric molecules. Finally, a review of the various methods used to resolve racemic mixtures will be provided. PREREQ: CHMI 2427. (lec 3) cr 3. Lecture (3.00).

The biosynthesis and biological activity of the following metabolites, polyketides, terpenes, metabolites from the shikimic acid pathway, and those from amino acids and of mixed biosynthetic origins will be presented. The sensory properties of some of the products will be shown as well as the role of others in chemical ecology during living-organism interactions. PREREQ: CHMI 3416 or permission of the instructor. (lec 3) cr 3