Chemistry

This course provides an introduction to the fundamental principles of chemistry. Topics include atomic and molecular structure, nuclear chemistry, stoichiometry, the periodic table and periodicity, and the properties of solutions. PREREQ: Grade 12U level chemistry or CHMI 1041 or permission of the department. (lec 3, tut 1, lab 2) cr 3.

This course is a continuation of CHMI 1006. Topics include thermochemistry, chemical thermodynamics, kinetics, chemical equilibrium, acid-base chemistry, buffer solutions, electrochemistry and introductory organic chemistry. PREREQ: CHMI 1006 or 1041 (min. 80%). (lec 3, tut 1, lab 3) cr 3.

This course provides an introduction to the underlying concepts of chemistry for the student with no background in chemistry. Topics include the states and properties of matter, the development of atomic theory and the periodic table, chemical equations, and ionic and covalent bonding (Lewis structures and the concept of molecular shape based on Valence Shell Electron Pair Repulsion). These discussions are followed by a brief introduction to the properties and manufacturing of materials of the heavy chemicals industry including acids, bases, salts, metals, and polymers. cr 3. Available only through the Centre for Continuing Education. Not available for credit for students in Chemistry or Biochemistry programs. Students may not retain credit for more than one of CHMI 1031 and CHMI 1041.

This course provides an introduction to the main classes of organic compounds. Nomenclature and chemical bonding as applied to carbon compounds are explained. Reaction types and concepts such as functional group and stereochemistry are discussed. The properties of organic molecules are related to their structural features. PREREQ: CHMI 1031, 1041 or equivalent. cr 3. Offered through the Centre for Continuing Education. Not available for credit for students in Chemistry or Biochemistry programs. Students may not retain credit for more than one of CHMI 1032 and CHMI 1202.

This course prepares students with little or no background in chemistry for CHMI 1202. Topics include the classification of matter, atomic structure, ionic and covalent bonding with an emphasis on the structure of organic molecules, acid-base equilibria including the role of pH and buffers in the health sciences, nuclear chemistry, nuclear energy, stoichiometry, the mole concept, solutions and chemical equilibria and their roles in the health sciences. (lec 3, lab/tut 2) cr 3. Students may not retain credit for more than one of CHMI 1031 and CHMI 1041.

This course provides an introduction to organic chemistry with emphasis on the structure, physical properties, nomenclature and chemical reactions of alkanes, alkenes, alkynes, cyclic aliphatic and aromatic compounds, alcohols, ethers, aldehydes, ketones, carboxylic acids, amines as well as select sulfur and phosphorus-containing compounds. It examines the structure and function of common carbohydrates such as glucose and its polymers, amino acids, peptides and proteins, an introduction to enzymes, DNA and RNA, the problem of DNA replication and protein synthesis. PREREQ: Grade 12 U level credit in Chemistry or CHMI 1041. (lec 3, lab/tut 2) cr 3. Students may not retain credit for more than one of CHMI 1032 and CHMI 1202.

In this course, the structure, properties and importance of the following classes of natural products will be discussed: amino acids, peptides and proteins, carbohydrates, lipids, terpenes, steroids, alkaoids and flavonoids. The structure and importance of some enzymes, vitamins and hormones will also be presented. The course will also include an introduction to metabolism and biological energy production. PREREQ: CHMI 1032 or equivalent cr 3. This course is not a credit course for students enrolled in a Chemistry or Biochemistry program.

This course introduces the basic concepts of environmental chemistry and natural ecosystems. The structure of the atmosphere and the important photochemical reactions occurring in the troposphere and the stratosphere, as well as the consequences of the ozone layer depletion, the continuous increase of carbon dioxide emissions and acid rain, are discussed. The basic concepts of limnology and aquatic chemistry are introduced. Eutrophication and water pollution by trace metals are also studied. Pollution by organic compounds is discussed using soils as examples. Some techniques of wastewater treatment and pollution remediation are discussed. PREREQ: CHMI 1202, 1032 or 1007. cr 3. This course is not a credit for students enrolled in the chemistry or Biochemistry program.

This course examines the theory and techniques of classical quantitative analysis, including gravimetry and precipitation titrations, volumetric analysis, oxidation-reduction titrations, complexometric titrations, as well as the treatment of data. Introductory notions of instrumental techniques are presented. PREREQ: CHMI 1006/7. Students registered in the specialized program in Chemistry with an average of at least 80% in CHMI 1006 may take CHMI 2117 in lieu of CHMI 1007. (lec 3, lab 3) cr 3.

This course is designed for nursing students to develop an appreciation, largely on the basis of case studies, of the relationship between various common diseases, the underlying biochemistry and the clinical tests used in their diagnosis. PREREQ: Grade 12 U level Chemistry, CHMI 1041 or CHMI 1031, or equivalent. (lec 3, lab, tut 3) cr 6. Not available for credit for students in Chemistry or Biochemistry programs

This course introduces the structure and function of proteins and nucleic acids. Topics include protein structure and function, nucleic acid chemistry, DNA and its replication, the genetic code and protein synthesis, regulation of gene expression, cloning and gene isolation, DNA sequencing, and enzyme kinetics. PREREQ: CHMI 2426. (lec 3, lab 3) cr 3.

This course presents an overview of the periodic table and the periodic properties of the elements. The various types of chemical bonding and the structures of solids are covered. A systematic study of the properties and chemical reactions of the Main Group elements is included. PREREQ: CHMI 1006/7. (lec 3, lab 3) cr 3.

This course presents an introduction to organic chemistry. Topics include structure and bonding, nomenclature, stereochemistry, and an introduction to the chemistry of a few classes of organic compounds. PREREQ: CHMI 1006/7. (lec 3, lab 3, tut 1) cr 3.

This course includes a detailed investigation of the reactions of hydrocarbons and monofunctional organic compounds. The factors which affect these reactions are also discussed. PREREQ: CHMI 2426. (lec 3, lab 3, tut 1) cr 3.

This course introduces the principles of chemical thermodynamics including the first, second and third laws of thermodynamics and the relations of thermodynamic functions to chemical equilibria in the ideal and nonideal solid, liquid and gaseous states. It includes elementary applications of the phase rule. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2516 and CHMI 2526.

This course introduces the physico-chemical principles of electrochemistry, chemical kinetics, surface and colloid chemistry. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2517 and CHMI 2527.

This course introduces the principles of chemical thermodynamics including the first, second and third laws of thermodynamics and the relations of thermodynamic functions to chemical equilibria in the ideal and nonideal solid, liquid and gaseous states. It includes elementary applications of the phase rule. PREREQ: CHMI 1006/7 and MATH 1036. (lec 3, lab equivalent workload, tut 1) 3 cr. No credit for students in Chemistry or Biochemistry programs. Students may not retain credit for both CHMI 2526 and CHMI 2516.

This course consists of an introduction to the physiochemical principles of electrochemistry, chemical kinetics, and surface and colloid chemistry. PREREQ: CHMI 1006/1007 and MATH 1036/1037. (lec 3, tut 1) cr 3. This course cannot be used for credit by students enrolled in the BSc Chemistry or Biochemistry program. Students cannot retain credit for both CHMI 2527 and CHMI 2517.

This course describes the main aspects of the chemistry and industrial operations of the production of inorganic chemicals. It is designed to provide an understanding of the present state of the chemical industry in terms of production of fine and heavy inorganic chemicals. PREREQ: CHMI 1031/2, or CHMI 1041 and 1202, or CHMI 1006/7. (lec 3) cr 3. May be chosen as an elective for students in Biochemistry and Chemistry. Students may not retain credit for both CHMI 3031 and CHMI 3030.

The course presents the principles and components of modern instruments currently used in chemical, biological, biochemical and environmental sciences, including forensic and pharmaceutical sciences to measure and characterize elements, ions, small and large molecules and compounds. It covers the main divisions of instrumental anyalysis based on: 1) separation techniques such as gas, liquid and supercritical chromatography, electrophoresis, gel permeation/filtration; 2) spectroscopy, spectrometry and optical phenomena such as ultra-violet, visible, infra-red, luminescence and fluorescence techniques, atomic spectrometry, surface plasmon resonance, X-ray techniques, radioactivity measurements, mass spectrometry; and 3) electrochemical methods based on potentiometry, voltammetry and biosensors. The interfacing of instruments (hyphenated techniques) is also covered and numerous applications are presented. PREREQ: CHMI 2117. (lec 3, lab 3) cr 3.

This course will cover advanced concepts in genome structure and function. The topics to be covered include DNA structure, structure of chromatin, unique and repetitive sequences in genomic DNA, DNA replication, repair and recombination and the control of gene expression. PREREQ or COREQ: CHMI 3226. Accepted as a credit towards a program in Biology. Students may not retain credit for both CHMI 3217 and CHMI 4216. Lecture (3.00). Equivalent to CHMI-4216FL, CHMI-4216EL, CHMI-4216EL, CHMI-4216FL. Prerequisites: take CHMI-2227EL.

Topics include: intermediary metabolism of carbohydrates, lipids, and amino acids; regulation of metabolism; membrane structure and functions; transmembrane signalling and photosynthesis. PREREQ: CHMI 2227 & CHMI 2427 or 2425. (lec 3, lab 3) cr 3 Lecture (3.00). Equivalent to CHMI-3226FL, CHMI-3226EA.

This course will give students hands-on experience with the techniques used in the biochemistry laboratory. The following techniques will be introduced: cell fractionation, protein and nucleic acid extraction and analysis, use of radioisotopes in biochemistry, spectroscopic techniques, preparation and characterization of liposomes and recombinant DNA techniques. PREREQ: successful completion of the second year in the biocchemistry program and CHMI 3226. (lab 6) cr 3. Lab (3. 00).

Students will study various concepts dealing with how the body interacts with drugs. They will first learn the routes of administration for drugs based on physico-chemical properties. They will then be introduced to the basic concepts of pharmacokinetics, pharmacodynamics and drug distribution, metabolism and elimination. Finally, the mechanism of action of drugs on the central nervous, cardiovascular, renal, gastrointestinal, immune and respiratory systems, and toxicology of drugs will be reviewed. PREREQ: CHMI 3226 and CHMI 3416. (lec 3) cr 3. Lecture (3.00).

This course addresses more advanced concepts in inorganic chemistry including electron counting rules for organometallic compounds and the isolobal concept. The synthesis and properties of organometallics and metal clusters are considered, as well as their use in homogeneous industrial cataysis. PREREQ: CHMI 2317. (lec 3, lab 3) cr 3. Lecture (3.00), Lab (3.00). Equivalent to CHMI-3317EL, CHMI-3317FL.

This course introduces the principles of aquatic chemistry of surface, soil and ground waters. Topics include the hydraulic cycle and cycling of elements in nature, ionic constituents of natural waters, solution chemistry, acid-base chemistry, precipitation and dissolution, hydrolysis of cations, the carbonate system, redox principles, and geochemical computer modelling. Applications to waste water treatment, water pollution/ contamination and related environmental problems will be examined. PREREQ: CHMI 2316 or GEOL 2807. (lec 3) cr 3.

This course covers the spectroscopic methods used to determine the structure of organic compounds. The techniques presented include ultraviolet-visible (UV-Vis), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies and mass spectrometry (MS). PREREQ: CHMI 2427. (lec 3, lab 3) cr 3.

This course examines condensation reactions involving carbanions and their application to synthesis, the chemistry of selected polyfunctional compounds and heterocyclic compounds, as well as molecular rearrangements and their mechanisms. Includes a study of the properties of the reactive intermediates in organic chemistry, photochemistry and the chemistry of organometallic compounds. PREREQ: CHMI 3416. (lec 3, lab 3) cr 3.

Explores the basic concepts of medicinal chemistry. An understanding of structure and stereochemistry and of chirality and drug design is developed. Drug activity is discussed in general terms of structure-activity relationships such as observed in the interaction of enzymes with substrates and inhibitors, and receptors with agonists and antagonists. Selective drugs and their mode of action include sulfa drugs, B-lactam antibiotics, agents to control Parkinson?s disease and anticancer drugs. PREREQ: CHMI 2427 and 2227. (lec 3) cr 3 Lecture (3.00).

This course presents advanced aspects of modern spectroscopy for the characterization of molecular structure and dynamics. It begins with an exposition of group theory, character tables and symmetry coordinates applied to the prediction of infrared and Raman activity. The accurate simulation of vibrational spectra using modern computational chemistry is outlined. The course discusses advances in photoelectron and electron- impact spectroscopy, pump-probe techniques for femto- and attosecond molecular and electronic dynamics, and new developments in single-molecule fluorescence spectroscopy. Also covered are modern techniques for single-molecule manipulation involving the use of scanning-probe microscopes, as well as optical and magnetic tweezers. PREREQ: CHMI 3537 (lec 3) cr 3. Lecture (3.00). Equivalent to CHMI-3536FL.

Examines the general mathematical principles of quantum chemistry and the application of these principles in interpreting atomic and molecular structure. PREREQ: CHMI 1006/7 & MATH 1036/7. MATH 1057 is recommended. (lec 3, lab 3) cr 3 Lecture (3.00). Equivalent to CHMI-3537FL.

This course examines coordination chemistry with emphasis on the d-block elements, including structure, reaction mechanisms, kinetics, and spectroscopy. Various bonding models such as valence bond theory, crystal/ligand field theory and molecular orbital theory are described. Electronegativity models, acid/base concepts, elements of symmetry (point groups) as well as aspects of organometallic chemistry, industrial processes and bioinorganic chemistry are also discussed. PREREQ: CHMI 2316. (lec 3, lab 3) cr 3. Students may not retain credit for both CHMI 2317 and CHMI 3316.

This course covers the 12 principles of green chemistry, atom economy and methods to reduce toxicity and wastes. Synthetic routes using green reagents, catalysts and solvents as well as renewable resources and alternative energy sources are examined. The application of green chemistry in major industrial processes is considered in the context of implementing clean technology and sustainability. Pre-req: CHMI 2426 and CHMI 2316. (lec 3) cr 3.

This course is designed for students enrolled in a science program to gain practical experience in their field of study. The placement must be approved by the course instructor. (exp 3) 3cr. PREREQ: Having completed at least 60 cr of a Bachelor of Science degree. Students cannot use their NATS 4005 lab experience to satisfy the requirements for NATS 3206.

This course will review the fundamental aspects of radioactivity, plus specific instrumentation and chemical analysis. The review topics include: types of ionizing radiation, units, nuclear stability, binding energy, growth and decay. The instrumentation and analysis will focus primarily on liquid scintillation and gamma spectroscopy analysis, the selection of energy range for quantification, counting statistics, efficiency correction (e.g. quenching), and background correction. Advanced topics include reactor life cycle and nuclear waste management, plus other topics that may vary from year to year: alpha spectroscopy; sample preparation techniques, decay chains (alpha emitters), isotope geology and dating, environmental actinide chemistry, etc. PREREQ: CHMI 3116 and MATH 2246 or CHMI 2516. (lec 3, lab 3) cr 3.

This course covers the analysis of environmental samples from sources such as lakes, rivers, sediments and effluents. Methods of studying the speciation of various elements present in the samples are also examined. Prerequisite: CHMI 3116E. (lec 3) cr 3.

This course will enable students to learn and apply several bioinformatics tools to the study of genomes and proteomes. The topics covered will include the sequencing and annotation of genomes, characterization of proteomes, comparative methods for sequence analysis, phylogenetic analysis, predictive methods for protein and nucleic acid sequence analysis, comparative methods for gene expression analysis and functional genomics. PREREQ: CHMI 3217. (3h) cr 3 Students may not retain credit for both CHMI 4206 and CHMI 3206. Lecture (3.00). Equivalent to CHMI-3206EL.

A discussion of the structure and function of membrane systems, such as myelin, plasma, mitochondrial, chloroplast and bacterial membranes. Examines the dynamic aspects associated with membranes such as transport of ions and metabolites, the transduction of energy and receptor-effector interactions. PREREQ: CHMI 3226. (lec 3) cr 3 Lecture (3.00). Equivalent to CHMI-4217FL.

This course is an introduction to several of the modern laboratory techniques involved in the manipulation of the DNA molecule. The following topics will be discussed: complimentary DNA and genomic library screening; PCR (polymerase chain reaction) technology; site-directed mutagenesis; DNAse footprinting procedure; transgenic and knock-out mice; in-vitro and in-vivo expression of specific proteins; cloning hereditary disease-causing genes; recombinant DNA and its commercial applications. PREREQ: CHMI 3217 (lec 3) cr 3. Students may not retain credit for both CHMI 4226 and CHMI 3216. Lecture (3.00). Equivalent to CHMI-3216FL, CHMI-4226FL.

Topics selected from recent literature on cellular and medical biochemistry are studied in depth. PREREQ: CHMI 3226. (lec 3) cr 3.

This course examines the biochemical and genetic adaptations of living organisms to various environmental factors. Stresses mediated by effectors such as temperature, water, salt, hydrogen ions, radiation, chemical pollutants, both metals and non-metals, and nutrients are examined. PREREQ: CHMI 3226. (lec 3) cr 3.

Examines the biochemical principles and cellular and molecular mechanisms that contribute to the manifestation of toxicity caused by drugs and environmental chemicals with emphasis on potential routes of uptake, the enzymes which catalyze biotransformation of xenobiotics, storage and elimination. The chemical reactivity, enzymatic induction and inhibition, the role of the cytochrome P-450-dependent mixed-function oxidase system in the deactivation and bioactivation of xenobiotics and glutathione conjugation are also presented. Topics include: reproductive toxicology and teratology, developmental toxicology, carcinogenesis, genotoxicity and mutagenesis, immunotoxiocology, neurotoxicology, environmental toxicology, clinical and regulatory toxicology, human health and ecotoxicological risk assessments. Selected classes of compounds and their exposure routes, mechanisms of toxicity, fate, toxicologic sequelae and their antidotes are considered in depth. PREREQ: CHMI 3226. (lec 3) cr 3 Lecture (3.00).

An introduction to the molecular aspects of the immune response. Topics include: structure, synthesis and function of antibodies, the nature of the antibody/antigen interaction, structure of the antigen receptors and of the MHC (Major Histocompatibility Complex) molecules, structure of the major cytokines and their receptors, and major molecular events involved in immune response. PREREQ: CHMI 3226 (may be taken concurrently). (lec 3) cr 3 Lecture (3.00). Equivalent to CHMI-4297FL.

This course explores selected topics in inorganic chemistry, such as solid state chemistry and industrial inorganic chemistry. PREREQ: CHMI 3317. (lec 3) cr 3

his course will describe how medicinal compounds are discovered from diverse sources. The use of organic chemistry to modify lead compounds will first be studied, with a particular emphasis on the optimization of the molecular structure to overcome undesired pharmacokinetics and pharmacodynamic properties. The students will then be introduced to modern methods of chiral synthesis for the production of enantiomeric molecules. Finally, a review of the various methods used to resolve racemic mixtures will be provided. PREREQ: CHMI 2427. (lec 3) cr 3. Lecture (3.00).

The kinetic and non-kinetic methods of determining the mechanisms of organic reactions are discussed in detail. Structure reactivity relationships and the effects of solvent and other physical parameters on the rates and mechanisms of reactions are also investigated. PREREQ: CHMI 3416. (lec 3) cr 3.

The biosynthesis and biological activity of the following metabolites, polyketides, terpenes, metabolites from the shikimic acid pathway, and those from amino acids and of mixed biosynthetic origins will be presented. The sensory properties of some of the products will be shown as well as the role of others in chemical ecology during living-organism interactions. PREREQ: CHMI 3416 or permission of the instructor. (lec 3) cr 3

An introduction to statistical ensembles of closed and open systems, and their use to compute thermodynamic properties from microscopic information. Topics include: classical and quantum statistics, partition functions, and their use in the calculation of thermodynamic properties of gases and solids. The course also covers the application of statistical mechanics in reaction-rate theory of chemical reactions. Students may not retain credit for both CHMI 4537 & 4576. PREREQ: CHMI 3536/7 or department?s permission. (lec 3) cr 3

This course presents recent advances in the characterization of molecular structure and dynamics at a very high time- and spatial- resolution. Particular emphasis is made on modern spectroscopic and spectrometric methods for the study of clusters and biomolecules, including light scattering and size analysis, confocal microscopy, photoacoustic and advanced infrared techniques, circular dichroism, coherent anti- Stokes Raman spectroscopy (CARS), as well as extended X-ray absorption fine structure (EXAFS) and other applications of synchrotron radiation. The course will also cover advances in techniques for the study of adsorbed biomolecules, including scanning probe techniques (STM and AFM), electrchemical methods, and differential scanning calorimetry. PREREQ: CHMI 2517 and CHMI 3536. (lec 3, tut 1.5) cr 3.

This course examines, in detail, theoretical approaches to chemical reactivity, computer-aided molecular modelling and drug design, and molecular dynamics simulations. Special emphasis is placed on computer simulations of liquids, solid-gas adsorption, drug-receptor interaction, protein folding, and the computation of thermodynamic properties by using statistical mechanics and molecular dynamics. Computer experiments form an essential part of the course. PREREQ: CHMI 3537. (lec 3) cr 3.

The 4th-year student is required to carry out a research project under the supervision of a staff member chosen by the student. The research project is written as a B.Sc. thesis according to the format available from the Department of Chemistry and Biochemistry. The student must give a seminar on the topic of her/his choice in the 2nd term. PREREQ: successful completion of 3rd year or instructor?s permission. (lab 9 min., sem 1) Lecture (3.00).