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Guangdong Yang

Guangdong Yang

Full Professor, School of Natural Sciences
School of Natural Sciences
Science, Engineering and Architecture
F-309, Science Building
705.675.1151 ext 2350 gyang2@laurentian.ca

Biography

07/2021-present, Full Professor, Laurentian University, Sudbury, Canada

07/2015-06/2021,  Associate Professor,  Laurentian University, Sudbury, Canada

7/2012-06/2015,  Research Associate Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

3/2007-06/2012,  Research Assistant Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

9/2006-2/2007, Postdoctoral Fellow, Department of Biology, Lakehead University, Thunder Bay, Canada

10/2002-9/2006, Postdoctoral Fellow, Department of Physiology, University of Saskatchewan, Saskatoon, Canada

Education


Academic Appointments


On The Web

http://scholar.google.ca/citations?user=iyRAPdgAAAAJ&hl=en

Download vCard gyang2@laurentian.ca 705.675.1151 ext 2350

Research

I have a strong interest in gasotransmitter, biomolecular science, and signal transduction research. There are three areas of on-going research programs and interests funded by NSERC and HSFC, including: 1) Biological significance of H2S-mediated protein translational modification; 2) Roles of H2S in cell behaviours; 3) Regulation and function of H2S in iron metabolism.

 

 

Awards

  • Merit increment, Laurentian University (2023)
  • New Investigator Award, Heart and Stroke Foundation of Canada (2009-2014)
  • Maureen Andrew New Investigator Award from Heart and Stroke Foundation of Ontario (2009), given to the highest rated Ontario New Investigator in the national competition who clearly demonstrates excellence in the area of cardiovascular or cerebrovascular research.
  • Heart and Stroke Foundation of Canada Research Fellowship (2006-2007)
  • Saskatchewan Health Research Foundation Post-Doctoral Fellowship (2004-2005)

Teaching

CHMI-5606EL- Research Seminar in Chemistry (2022 fall)

CHMI-5005EL- Critical Review Essay (2022 fall)

CHMI-5000EL/FL- Thesis (2022 fall)

CHMI-5236EL- Molecular Biology of Eukaryotes (2016 winter, 2017 winter, 2021 winter)

CHMI-5246EL- Selected Topics - Biochemistry (2016 winter, 2016 fall, 2018 fall, 2023 fall)

CHMI-4615EL- Research Seminar (2018 fall/2019 winter/coordinator)

CHMI-4446EL- Drug Design and Development (2020 winter/group teaching)

CHMI-4256EL- Biochemistry of Diseases (2016-2018 fall, 2020-2022 winter, 2024 winter)

CHMI-4237EL- The RNA world (2021 winter, 2024 fall)

CHMI-4207EL- Advanced Cellular Biochemistry (2017 winter, 2018 winter)

CHMI-3227EL/FL- Experimenal Biochemistry (2018-2020 winter, 2022 winter, 2023 winter)

CHMI-2220EL-10- Clinical Chemistry (2020-2024 spring)

CHMI-2031EL-10- Natural Products-Organic & Biochemical Features (2023 winter, 2024 winter)

BIOL-2701EL 12- Human Physiology (2022 fall, 2024 winter)

BIOL-1700EL-12- The Structure and Functions of Human Body (2022 spring, 2023 spring, 2023 fall/2024 winter)

   

Publications

Selective publications since 2014 (#, trainee; *, corresponding author).

  1. Ligi S#, Ali A#, Yang G*. Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice. Nitric Oxide. 2024, 151:1-9. 

  2. Linjacki S#, Wang Y#, Baath N#, Mantle D#, Yang G*. H2S protects from rotenone-induced ferroptosis by stabilizing Fe-S clusters in rat cardiac cells. Cells. 2024, 13(5):371. 

  3. Harvey F#, Aromokunola B#, Montaut S*, Yang G*. The antioxidant properties of glucosinolates in cardiac cells are independent of H2S signaling. Int. J. Mol. Sci. 2024, 25(2), 696.

  4. Yu R#, Wang Y#, Zhu J#, Yang G*. H2S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence. Arch Physiol Biochem. 2024, 130(1):96-109. 

  5. Yang G*. Targeting selective E3 ligase for healing cardiac fibrosis (preview). Cell Chemical Biology. 2023, 30:1188-1190.

  6. Zhu J#, Wang Y#, Rivett A#, Yang G*. H2S regulation of iron homeostasis by IRP1 improves vascular smooth muscle cell functions. Cell Signal. 2023, 110:110826.
  7. Zhu J#, Wang Y#, Rivett A#, Li H, Wu L, Wang R, Yang G*. Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice. J Mol Cell Cardiol. 2022, 171:30-44.

  8. Barrow K#, Wang Y#, Yu R#, Zhu J#, Yang G*. H(2)S protects from oxidative stress-driven ACE2 expression and cardiac aging. Mol Cell Biochem. 2022, 477:1393-1403.

  9. Read E#, Milford J#, Zhu J#, Wu L, Bilodeau M, Yang G*. The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021, 426:115642.

  10. Zhang Y#, Masters L#, Wang Y#, Wu L, Pei Y, Guo B, Parissenti A, Lees SJ, Wang R, Yang G*. Cystathionine gamma-lyase/H2S signaling facilitates myogenesis under aging and injury condition. The FASEB J. 2021, 35:e21511.
  11. Wang Y#, Yu R#, Wu L, Yang G*. Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation. Cell Signal. 2021, 78:109870.
  12. Yang G*. H2S as a potential defence against COVID-19? Am J Physiol Cell Physiol. 2020, 319(2):C244-C249.
  13. Ali A#, Zhang Y#, Fu M, Pei Y, Wu L, Wang R, Yang G*. Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice. Life Sci. 2020, 252:117661.
  14. Zhang Y#, Wang Y#, Read E#, Fu M, Pei Y, Wu L, Wang R, Yang G*. Golgi stress respone, H2S metabolism, and intracellular calcium homeostasis. Antioxid Redox Signal. 2020, 32:583-601.
  15. Greasley A#, Zhang Y#, Wu B, Pei Y, Belzile N, Yang G*. H2S protects against cardiac cell hypertrophy through regulation of selenoproteins. Oxid Med Cell Longev. 2019, 10:6494306.
  16. Zhang Y#, Ali A#, Jin Z, Pei Y, Yang G*. Induction of cystathionine gamma-lyase expression and metallothionein-1 S-sulfhydration alleviate cadmium-induced cell death in myoblast cells. Ecotoxicol Environ Saf. 2019, 179:222-231.
  17. Stokes E#, Shuang T, Zhang Y#,  Pei Y, Fu M, Guo B, Parissenti A, Wu L, Wang R, Yang G*. Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells. Life Sci. 2018, 213:116-125.  
  18. Loiselle JJ#, Yang G*, Wu L*. Hydrogen sulfide and hepatic lipid metabolism – a critical pairing for liver health. Br J Phamcol. 2018, 177:757-768.
  19. Racine M#, Shuang T, Zhang Y#, Fu M, Pei Y, Wu L, Wang R, Yang G*. Reversal of Sp1 transactivation and TGF1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation. Toxicol Appl Pharmacol. 2018,356:25-35. 
  20. Yang G*, Ju Y#, Fu M, Thomas M, Racine M#, Batth S, Pei Y, Wang R, Wu L. Cystathionine gamma-lyase/H2S system is essential for adipogenesis and fat mass formation in mice. BBA Molecular and Cell Biology of Lipids. 2017,1863:165-176.
  21. Bourque C#, Zhang Y#, Fu M, Racine M#, Greasley A#, Pei Y, Wu L, Wang R, Yang G*. H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells. Toxicol Appl Pharmacol. 2017,338:20-29.
  22. Ju Y#, Untereiner A, Wu L, Yang G*. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. BBA - General Subjects. 2015, 1850:2293-303.
  23. Li S#, Yang G*. H2S regulation of DNA methylation and mitochondrial DNA copy number. Antioxid. Redox Signal. 2015, 23:630-42.
  24. Zhao K#, Li S#, Wu L, Lai C, Yang G*. H2S represses androgen receptor transactivation by targeting at the second zinc-finger module.  J. Biol. Chem. 2014, 289:20824-35. 
  25. Zhao K#, Ju Y#, Li S#, Zaid Al Taany, Wang R*, Yang G*. Mediation of PARP and MEK1 in H2S-protected DNA damage repair response. EMBO report. 2014, 15:792-800. 

Please see the full publication list from Google scholar:  http://scholar.google.ca/citations?user=iyRAPdgAAAAJ&hl=en