Mazen Saleh

Mazen Saleh

Chairperson | Associate Professor

Department of Biology
Science, Engineering and Architecture
S-724, Science Building Sudbury Campus

Biography

Following my undergraduate and Master's studies at the University of Waterloo, I joined the Department of Medical Biophysics at the University of Toronto. Under the supervision of Professor Jean Gariepy, my doctorate studies were focused on the biophysics of microbial protein toxins. Prior to joining the Department of Biology at Laurentian University, I spent time as a postdoctoral fellow at the University of California at Los Angeles (UCLA) and Colorado State University.

Education

  • B.Sc. (university of Waterloo)
  • M.Sc. (University of Waterloo)
  • Ph.D. (University of Toronto)

Academic Appointments

Associate Professor - Laurentian University

Associate Professor - Northern Ontario School of Medicine

On The Web

http://oldwebsite.laurentian.ca/biology/msaleh/index.htm

Research

The area of my expertise is molecular biophysics. My training in this area has been used in the past 15 years to study various aspects of bacterial physiology and their interactions with their environments. Several research programs were carried out in relation to interaction of bacteria with their environments in both pathogenic and non-pathogenic bacteria. In non-pathogenic bacteria, I used bioinformatics techniques to address certain questions on the process of protein secretion in bacteria. Specifically, how the structural features of signal sequences direct the membrane translocation of signal sequence-containing secretory proteins. I currently have a graduate student looking at the involvement of the mRNA of such secretory proteins in targeting the protein to the membrane for translocation and secretion.

In terms of other aspects of bacterial protein secretion (relevant to pathogenesis), I'm interested in the secretion mechanisms and characterization of bacterial extracellular polypeptides. My group is involved in several projects at the present time to include work with RNA-binding proteins and their role in protein secretion, physiological and immunological comparative studies of Streptomyces and Mycobacteria, and the cloning and characterization of a number of virulence factors of Mycobacteria and Streptomyces.

Awards

  • Teaching

    BIOL 2026 EL - Principles of Microbiology

    BIOL 2036 EL - Microbiology for the Health Sciences

    BIOL 2126 EL - Cell Biology

    BIOL 3117 EL - Infectious Diseases 

    BIOL 5026 EL - Advanced Microbiology I

    Publications

    • Voros A, DeLongchamp J, Saleh M (2015) The Secretome of Mycoplasma capricolum subsp. capricolum in Neutral and Acidic Media. J Proteomics Bioinform 8:155-163. doi: 10.4172/jpb.1000364
    • Hewage, N. and Saleh, M. (2015) Evaluation of the Pathogen Detect® System and Anthracene-Based Enzyme Substrates for the Detection and Differentiation of E. coli and Total Coliforms in Water Samples. Journal of Water Resource and Protection, 7, 689-701. doi: 10.4236/jwarp.2015.79056.
    • Evans, S. and Saleh, M. (2015) Cyanobacteria Diversity in Blooms from the Greater Sudbury Area. Journal of Water Resource and Protection, 7, 871-882. doi: 10.4236/jwarp.2015.711071.
    • Hoang-Yen Thi Truong, Yu-Wei Chen, Mazen Saleh, Susan Nehzati,Graham N. George, Ingrid J. Pickering and Nelson Belzile (2014) Proteomics of Desulfovibrio desulfuricans and X-ray absorption spectroscopy to investigate mercury methylation in the presence of selenium. Metallomics 6:465-475.
    • Farag Bleiblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar, and Aseem Kumar (2012) The Role of Immunostimulatory Nucleic Acids in Septic Shock. Int J Clin Exp Med 5(1):1-23 www.ijcem.com /ISSN:1940-5901/IJCEM1112008
    • Farag Bleiblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar, Aseem Kumar (2012) Bacterial RNA induces myocyte cellular dysfunction through the activation of PKR. J Thorac Dis. DOI: 10.3978/j.issn.2072-1439.2012.01.07
    • Danielle Brabant, Paul Michael, Farag Bleiblo, Mazen Saleh, Ravin Narain, T.C. Tai, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar, and Aseem Kumar (2011) Septic sera induces apoptosis and DNA fragmentation factor 40 activation in fibroblasts. Biochem Biophys Res Com 412:260–265.
    • Amanda Voros, Ashley Dunnett, Leo G. Leduc, and Mazen T. Saleh (2009) Depleting proteins from the growth medium of Mycoplasma capricolum unmasks bacterium-derived enzymatic activities. Vet. Microbiol. 138: 384-389.
    • Catharine Song, Aseem Kumar, and Mazen T. Saleh (2009) Bioinformatic comparison of bacterial secretomes. Genom. Prot. Bioinform. 7: 37-46.
    • Mazen T. Saleh, Catharine Song, Sabah Nasserulla, and L.G. Leduc (2010) Indicators from archaeal secretomes. Microbiol. Res. 165(1): 1-10.