Biochemistry

This course provides an introduction to the fundamental principles of chemistry. Topics include atomic and molecular structure, nuclear chemistry, stoichiometry, the periodic table and periodicity, and the properties of solutions. PREREQ: Grade 12U level chemistry or CHMI 1041 or permission of the department. (lec 3, tut 1, lab 2) cr 3.

This course is a continuation of CHMI 1006. Topics include thermochemistry, chemical thermodynamics, kinetics, chemical equilibrium, acid-base chemistry, buffer solutions, electrochemistry and introductory organic chemistry. PREREQ: CHMI 1006 or 1041 (min. 80%). (lec 3, tut 1, lab 3) cr 3.

This course introduces Mendelian inheritance, chromosomes, and the chemical basis of heredity, linkage, and crossing over. Topics include variations in chromosome structure and number, mutation, the structure and function of genes, and the use of statistics in the genetic analysis of quantitative characters. PREREQ: BIOL 1506/1507. (lec 3, lab 3) cr 3. Students may not retain credit for both BIOL 2007 and either BIOL 2011 or BIOL 3017.

This course is an introduction to the field of microbiology, with emphasis on the bacteria. Topics include classificatiion, morphology and structure, and physiology and growth of microorganisms. PREREQ: BIOL 1506/1507 or grade 12U level Biology for non-Science students. (lec 3, lab 3) cr 3. Students may not retain credit for BIOL 2026 and either BIOL 2110, BIOL 2111 or BIOL 3025.

This course introduces molecular, structural and functional organization in both prokaryotic and eucaryotic cells. Topics include chemical composition of cells, plasma membrane, cell surface, cytoplasmic membranes, mitochondria and respiration, chloroplasts and photosynthesis, cytoskeleton, nucleus, cell division, DNA replication, and protein synthesis. PREREQ: BIOL 1506. (lec 3, lab 3) cr 3.

This course examines the theory and techniques of classical quantitative analysis, including gravimetry and precipitation titrations, volumetric analysis, oxidation-reduction titrations, complexometric titrations, as well as the treatment of data. Introductory notions of instrumental techniques are presented. PREREQ: CHMI 1006/7. Students registered in the specialized program in Chemistry with an average of at least 80% in CHMI 1006 may take CHMI 2117 in lieu of CHMI 1007. (lec 3, lab 3) cr 3.

This course introduces the structure and function of proteins and nucleic acids. Topics include protein structure and function, nucleic acid chemistry, DNA and its replication, the genetic code and protein synthesis, regulation of gene expression, cloning and gene isolation, DNA sequencing, and enzyme kinetics. PREREQ: CHMI 2426. (lec 3, lab 3) cr 3.

This course presents an overview of the periodic table and the periodic properties of the elements. The various types of chemical bonding and the structures of solids are covered. A systematic study of the properties and chemical reactions of the Main Group elements is included. PREREQ: CHMI 1006/7. (lec 3, lab 3) cr 3.

This course presents an introduction to organic chemistry. Topics include structure and bonding, nomenclature, stereochemistry, and an introduction to the chemistry of a few classes of organic compounds. PREREQ: CHMI 1006/7. (lec 3, lab 3, tut 1) cr 3.

This course includes a detailed investigation of the reactions of hydrocarbons and monofunctional organic compounds. The factors which affect these reactions are also discussed. PREREQ: CHMI 2426. (lec 3, lab 3, tut 1) cr 3.

This course introduces the principles of chemical thermodynamics including the first, second and third laws of thermodynamics and the relations of thermodynamic functions to chemical equilibria in the ideal and nonideal solid, liquid and gaseous states. It includes elementary applications of the phase rule. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2516 and CHMI 2526.

This course introduces the physico-chemical principles of electrochemistry, chemical kinetics, surface and colloid chemistry. PREREQ: CHMI 1006/7 and MATH 1036/7. (lec 3, lab 3, tut 1) cr 3. Students may not retain credit for both CHMI 2517 and CHMI 2527.

The basic software tools applicable to the sciences are presented. These include statistical tools such as SPSS or Minitab, spreadsheets and numerical tools such as Maple, Mathcad, or Matlab. PREREQ: MATH 1036 or permission of the instructor. (lec 3) cr 3. Students may not retain credit for both COSC 2836 and COSC 2831.

The organization of data, discrete distributions (binominal, Poisson), continuous distributions (uniform, normal and skewed), and linear combinations of variables are studied. The techniques of hypothesis testing and interval estimation are applied to problems involving means, variances, proportions, frequency tables, regression, and correlation. Students are introduced to the use of statistical computer software. PREREQ: MATH 1036. (lec 3, tut 1) cr 3. Students may only retain credit for one of STAT 2246, STAT 2126, STAT 2066, MATH 2261, MATH 2236, MATH 2246, or ENGR 2017.

The course presents the principles and components of modern instruments currently used in chemical, biological, biochemical and environmental sciences, including forensic and pharmaceutical sciences to measure and characterize elements, ions, small and large molecules and compounds. It covers the main divisions of instrumental anyalysis based on: 1) separation techniques such as gas, liquid and supercritical chromatography, electrophoresis, gel permeation/filtration; 2) spectroscopy, spectrometry and optical phenomena such as ultra-violet, visible, infra-red, luminescence and fluorescence techniques, atomic spectrometry, surface plasmon resonance, X-ray techniques, radioactivity measurements, mass spectrometry; and 3) electrochemical methods based on potentiometry, voltammetry and biosensors. The interfacing of instruments (hyphenated techniques) is also covered and numerous applications are presented. PREREQ: CHMI 2117. (lec 3, lab 3) cr 3.

This course will cover advanced concepts in genome structure and function. The topics to be covered include DNA structure, structure of chromatin, unique and repetitive sequences in genomic DNA, DNA replication, repair and recombination and the control of gene expression. PREREQ or COREQ: CHMI 3226. Accepted as a credit towards a program in Biology. Students may not retain credit for both CHMI 3217 and CHMI 4216. Lecture (3.00). Equivalent to CHMI-4216FL, CHMI-4216EL, CHMI-4216EL, CHMI-4216FL. Prerequisites: take CHMI-2227EL.

Topics include: intermediary metabolism of carbohydrates, lipids, and amino acids; regulation of metabolism; membrane structure and functions; transmembrane signalling and photosynthesis. PREREQ: CHMI 2227 & CHMI 2427 or 2425. (lec 3, lab 3) cr 3 Lecture (3.00). Equivalent to CHMI-3226FL, CHMI-3226EA.

This course will give students hands-on experience with the techniques used in the biochemistry laboratory. The following techniques will be introduced: cell fractionation, protein and nucleic acid extraction and analysis, use of radioisotopes in biochemistry, spectroscopic techniques, preparation and characterization of liposomes and recombinant DNA techniques. PREREQ: successful completion of the second year in the biocchemistry program and CHMI 3226. (lab 6) cr 3. Lab (3. 00).

This course covers the spectroscopic methods used to determine the structure of organic compounds. The techniques presented include ultraviolet-visible (UV-Vis), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies and mass spectrometry (MS). PREREQ: CHMI 2427. (lec 3, lab 3) cr 3.

This course examines condensation reactions involving carbanions and their application to synthesis, the chemistry of selected polyfunctional compounds and heterocyclic compounds, as well as molecular rearrangements and their mechanisms. Includes a study of the properties of the reactive intermediates in organic chemistry, photochemistry and the chemistry of organometallic compounds. PREREQ: CHMI 3416. (lec 3, lab 3) cr 3.

Explores the basic concepts of medicinal chemistry. An understanding of structure and stereochemistry and of chirality and drug design is developed. Drug activity is discussed in general terms of structure-activity relationships such as observed in the interaction of enzymes with substrates and inhibitors, and receptors with agonists and antagonists. Selective drugs and their mode of action include sulfa drugs, B-lactam antibiotics, agents to control Parkinson?s disease and anticancer drugs. PREREQ: CHMI 2427 and 2227. (lec 3) cr 3 Lecture (3.00).

This course is designed for students enrolled in a science program to gain practical experience in their field of study. The placement must be approved by the course instructor. (exp 3) 3cr. PREREQ: Having completed at least 60 cr of a Bachelor of Science degree. Students cannot use their NATS 4005 lab experience to satisfy the requirements for NATS 3206.

This course will enable students to learn and apply several bioinformatics tools to the study of genomes and proteomes. The topics covered will include the sequencing and annotation of genomes, characterization of proteomes, comparative methods for sequence analysis, phylogenetic analysis, predictive methods for protein and nucleic acid sequence analysis, comparative methods for gene expression analysis and functional genomics. PREREQ: CHMI 3217. (3h) cr 3 Students may not retain credit for both CHMI 4206 and CHMI 3206. Lecture (3.00). Equivalent to CHMI-3206EL.

A discussion of the structure and function of membrane systems, such as myelin, plasma, mitochondrial, chloroplast and bacterial membranes. Examines the dynamic aspects associated with membranes such as transport of ions and metabolites, the transduction of energy and receptor-effector interactions. PREREQ: CHMI 3226. (lec 3) cr 3 Lecture (3.00). Equivalent to CHMI-4217FL.

This course is an introduction to several of the modern laboratory techniques involved in the manipulation of the DNA molecule. The following topics will be discussed: complimentary DNA and genomic library screening; PCR (polymerase chain reaction) technology; site-directed mutagenesis; DNAse footprinting procedure; transgenic and knock-out mice; in-vitro and in-vivo expression of specific proteins; cloning hereditary disease-causing genes; recombinant DNA and its commercial applications. PREREQ: CHMI 3217 (lec 3) cr 3. Students may not retain credit for both CHMI 4226 and CHMI 3216. Lecture (3.00). Equivalent to CHMI-3216FL, CHMI-4226FL.

Topics selected from recent literature on cellular and medical biochemistry are studied in depth. PREREQ: CHMI 3226. (lec 3) cr 3.

This course examines the biochemical and genetic adaptations of living organisms to various environmental factors. Stresses mediated by effectors such as temperature, water, salt, hydrogen ions, radiation, chemical pollutants, both metals and non-metals, and nutrients are examined. PREREQ: CHMI 3226. (lec 3) cr 3.

Examines the biochemical principles and cellular and molecular mechanisms that contribute to the manifestation of toxicity caused by drugs and environmental chemicals with emphasis on potential routes of uptake, the enzymes which catalyze biotransformation of xenobiotics, storage and elimination. The chemical reactivity, enzymatic induction and inhibition, the role of the cytochrome P-450-dependent mixed-function oxidase system in the deactivation and bioactivation of xenobiotics and glutathione conjugation are also presented. Topics include: reproductive toxicology and teratology, developmental toxicology, carcinogenesis, genotoxicity and mutagenesis, immunotoxiocology, neurotoxicology, environmental toxicology, clinical and regulatory toxicology, human health and ecotoxicological risk assessments. Selected classes of compounds and their exposure routes, mechanisms of toxicity, fate, toxicologic sequelae and their antidotes are considered in depth. PREREQ: CHMI 3226. (lec 3) cr 3 Lecture (3.00).

An introduction to the molecular aspects of the immune response. Topics include: structure, synthesis and function of antibodies, the nature of the antibody/antigen interaction, structure of the antigen receptors and of the MHC (Major Histocompatibility Complex) molecules, structure of the major cytokines and their receptors, and major molecular events involved in immune response. PREREQ: CHMI 3226 (may be taken concurrently). (lec 3) cr 3 Lecture (3.00). Equivalent to CHMI-4297FL.

The kinetic and non-kinetic methods of determining the mechanisms of organic reactions are discussed in detail. Structure reactivity relationships and the effects of solvent and other physical parameters on the rates and mechanisms of reactions are also investigated. PREREQ: CHMI 3416. (lec 3) cr 3.

This course examines, in detail, theoretical approaches to chemical reactivity, computer-aided molecular modelling and drug design, and molecular dynamics simulations. Special emphasis is placed on computer simulations of liquids, solid-gas adsorption, drug-receptor interaction, protein folding, and the computation of thermodynamic properties by using statistical mechanics and molecular dynamics. Computer experiments form an essential part of the course. PREREQ: CHMI 3537. (lec 3) cr 3.

The 4th-year student is required to carry out a research project under the supervision of a staff member chosen by the student. The research project is written as a B.Sc. thesis according to the format available from the Department of Chemistry and Biochemistry. The student must give a seminar on the topic of her/his choice in the 2nd term. PREREQ: successful completion of 3rd year or instructor?s permission. (lab 9 min., sem 1) Lecture (3.00).

This course provides students with an understanding of the molecular events underlying a number of common human diseases. The topics include: metabolic diseases, cancer, pathologies of the hematopoietic, nervous and muscular systems, and congenital diseases. The course also includes an introduction to clinical biochemistry, and a description of novel molecular-based approaches to therapy. Prereq: CHMI 3226. (lec 3) cr 3.