Thomas Merritt

Thomas Merritt

Canada Research Chair

Department of Chemistry & Biochemistry
Science, Engineering and Architecture
F-310, Science Building Sudbury Campus

Education

  • 2000  Ph.D. – The evolution of vertebrate neural isozymes

     Department of Biological Sciences, University of South Carolina

  • 1995  M.Sc. – Regulation of the development of sex-specific genital muscles by the doublesexge

        Department of Zoology, Oregon State University, 

  • 1991  B.Sc. with Honors & Distinction

        Department of Biology, University of North Carolina, Chapel Hill.



Academic Appointments

07/14-present  Full Professor, Department of Chemistry & Biochemistry, Laurentian University

07/11-06/14     Associate Professor, Department of Chemistry & Biochemistry, Laurentian University

01/10-12/19     Tier 2 Canada Research Chair in Bioinformatics and Genomics, Department of Chemistry & Biochemistry,    Laurentian University

07/06-06/11     Assistant Professor, Department of Chemistry & Biochemistry, Laurentian University

07/05-07/06     Assistant Professor, Department of Biology, Long Island University; Research Professor, Department of Ecology and Evolution, Stony Brook University.

01/01-06/05     Post-Doctoral Associate, Department of Ecology and Evolution, Stony Brook University.

On The Web

https://laurentian.ca/dr-thomas-merritt

Awards

  • Publications

    Yang G, Y Ju, M Fu, Y Zhang, Y Pei, M Racine, S Baath*, TJSMerritt, R Wang, L Wu 2018 Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice. Biochim Biophys Acta. Feb;1863(2):165-176. doi: 10.1016/j.bbalip.2017.11.008.

    Doran*, M, N Mykytczuk, A Bieniek*, A Methé*, TJS Merritt 2017 Evaluation of Quenching and Extraction Procedures for Performing Metabolomics in Acidithiobacillus ferrooxidans. Metabolomics 13: 156. DOI 10.1007/s11306-017-1298-4

    Merritt, TJS, and AJ Bewick* 2017 Genetic Diversity In Insect Metal Tolerance. Frontiers in Genetics. 8: 172. doi: 10.3389/fgene.2017.00172

    Doran*⁠, ⁠ML, J M Knee⁠⁠*, N Wang⁠⁠, TZ Rzezniczak*⁠, TL Parkes, L Li⁠, TJS Merritt 2017 Metabolomic analysis of oxidative stress: Superoxide dismutasemutation and paraquat induced stress in Drosophila melanogaster. Free Radical Biology and Medicine. 113: 323–334. 

    Lessel* CE, TL. Parkes, J Dickinson, and TJS Merritt 2017 Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation in Drosophila melanogaster. G3 Gene, Genomes, Genetics 7: 2651-2664.

    de Carvalho, NR, NR Rodrigues, GE Macedo, IJ Bristot, AA Boligon, MM de Campos, FAB Cunha, HD Coutinho, F Klamt, TJS Merritt, T Posser, and JL Franco 2017 Eugenia uniflora Leaves Essential Oil Promotes Mitochondrial Dysfunction In Drosophila melanogasterThrough The Inhibition Of Oxidative Phosphorylation. Toxicological Research 6: 526-534.

    Auld*, RR, NCS Mykytczuk, LG Leduc, and TJS Merritt 2017 Seasonal variation in an acid mine drainage microbial community. Canadian Journal of Microbiology 63: 137-152.

    Cutler*, B, T Eger, TJS Merritt, A Godwin 2017 Comparing para-rowing setups on an ergometer using kinematic movement patterns of able-bodied rowers. Journal of Sports Sciences. 35(8): 777–783. 

    MacMillan, HA, JM Knee*, AB Dennis, H Udaka, KE Marshall, TJ S Merritt, BJ Sinclair 2016 Cold acclimation wholly reorganizes the Drosophila melanogastertranscriptome and metabolome. Scientific Reports DOI: 10.1038/srep28999

    Cutler*, B, TJS Merritt, T Eger, A Godwin 2015 Using Peak Vicon data to drive Classic JACK animation for the comparison of low back loads experienced during para-rowing. International Journal of Human Factors Modelling and Simulation 5(2): 99-112. 

    Bing*, X, TZ Rzezniczak*, JR Bateman, TJS Merritt 2014 Transvection-Based Gene Regulation in Drosophila Is a Complex and Plastic Trait. G3 4(11): 2175-2187.

    Knee*, JM, TZ Rzezniczak*, K Guo, A Barsh, TJS Merritt 2013 A novel ion pairing LC-MS metabolomics protocol for study of a variety of biologically relevant metabolites. Journal of Chromatography B 936: 63-73.

    Harniman*, R, TJS Merritt, LJ Chapman, D. Lesbarreres, ML Martinez 2013 Population differentiation of the African cyprinid Barbus neumayeriacross dissolved oxygen regimes. Ecology and Evolution 3(6): 1495-1506.

    Auld*, RR, M Myre*, NCS Mykytczuk, LG Leduc, and TJS Merritt 2013 Characterization of the Microbial Acid Mine Drainage Microbial Community using Culturing and Direct Sequencing Techniques. Journal of Microbiological Methods 93: 108-115.

    Auld*, R, JM Quattro, TJS Merritt 2012 Molecular evolution of teleost neural isozymes. Journal of Molecular Evolution 75: 198-213.

    Rzezniczak*, TZ and TJS Merritt 2012 Interactions of NADP-Reducing enzymes across varying environmental conditions: a model of biological complexity. G3 Gene, Genomes, Genetics 2: 1613-1623.

    Rzezniczak*, TZ, TE Lum*, R Harniman*, TJS Merritt 2012 A combination of structural and cis-regulatory factors drive biochemical differences in Drosophila melanogastermalic enzyme. Biochemical Genetics 50: 823-837.

    Paula, MT, AP Zemolin, AP Vargas, RM Golombieski, ELS Loreto, AP Saidelles, RS Picoloto, EMM. Flores, AB Pereira, JBT Rocha, TJS Merritt, JL Franco, and T Posser 2012 Effects of Hg(II) Exposure on MAPK Phosphorylation and Antioxidant System in D. melanogaster. Environmental Toxicology DOI: 10.1002/tox.21788.

    Babin-Fenske, JJ, TJS Merritt, JM Gunn, T Walsh*, and D Lesbarreres 2012 Phylogenetic analysis of Hyalella colonization in lakes recovering from acidification and metal contamination. Canadian Journal of Zoology 90:624-629.

    Lum*, TE and TJS Merritt 2011 Non-classical Regulation of Transcription: Interchromosomal-interactions at the Malic Enzyme Locus of Drosophila melanogasterGenetics 189: 837-849.

    Rzezniczak*, TZ, L Douglas*, JH Watterson, and TJS Merritt 2011 Paraquat administration in Drosophilafor use in metabolic studies of oxidative stress. Analytical Biochemistry 419:345-347. 

    Bernard*, KE, TL Parkes, and TJS Merritt 2011 A Model of Oxidative Stress Management: Moderation of Carbohydrate Metabolizing Enzymes in SOD1-Null Drosophila melanogaster. PLoS ONE 6:e24518.

    Merritt, TJS, L Douglas*, TZ Rzeznickzak*, and JH Watterson. 2011 Rapid and Simple Analysis of Paraquat in Tissue Homogenate by Ultra-High Performance Liquid Chromatography. Analytical Methods 419:345-347.

    Yang, C-S, MJ Thomenius, EC Gan, W Tang, CD Freel, TJS Merritt, LK Nutt, and S Kornbluth. 2010 Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. The EMBO Journal 29: 2715-2723.

    Merritt, TJS, C Kuczynski, E Sezgin, C-T Zhu, S. Kumagai, and W.F. Eanes. 2009. Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster. Genetics 182: 565-574.

    Eanes, WF, TJS Merritt, JM Flowers, S Kumagai and C-T Zhu. 2009. Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdhand Mdhl) affects adult ethanol tolerance in Drosophila melanogaster. Genetics 181: 607-614.

    Bernard, KE, TL Parkes and TJS Merritt. 2009. Teaching behavioural genetics using drosophila larval phototaxis. Drosophila Information Service 92: 172.

    Lum*, TECH and TJS. Merritt. 2008. Genotyping and enzyme activity measurements of the Adhpolymorphism: a simple exercise in population genetics, biochemistry, and the connection of genotype and phenotype. Drosophila Information Service 91: 155-156.

    Tremblay*, A, D Lesbarreres, TJS Merritt, and J Gunn. 2008. Genetic structure and phenotypic plasticity of yellow perch (Perca flavescens) populations influenced by habitat, predation, and contamination gradients.  Integrative Environmental Assessment and Management 4: 264-266.

    Eanes, WF, TJS Merritt, JM Flowers, S. Kumagai, E Sezgin, C-T Zhu.  2006 Flux Control and excess capacity in the enzymes of glycolysis and their relationship to flight metabolism in Drosophila melanogaster. Proc. Nat. Acad. Sci. USA 103: 19413-19418.

    Merritt, TJS, E Sezgin, C-T Zhu, and WF Eanes. 2006 Triglyceride pools, flight, and genetic variation at the Gpdhlocus in Drosophila melanogaster.  Genetics 172: 293-304.

    Merritt, TJS, DD Duvernell, and WF Eanes. 2005 Natural and synthetic alleles provide complementary insights into the nature of selection acting on the Men polymorphism of Drosophila melanogaster.  Genetics 171: 1707-1718.

    Merritt, TJS, CR Young, RG Vogt, RC Wilkerson, and JM Quattro. 2005. Intron retention identifies a malarial vector within the Anopheles (Nyssorhynchus) albitaris complex (Diptera: Culicidae). Molecular Phylogeneitcs and Evolution 35: 719-724.

    Matzkin, LM, TJS Merritt, C-T Zhu, and WF Eanes. 2005. The structure and population genetics of the breakpoints associated with cosmopolitan inversion In(3R)Paynein Drosophila melanogaster.  Genetics 170: 1143-1152. 

    Merritt, TJS and JM Quattro. 2003. Evolution of the vertebrate cytosolic malate dehydrogenase gene family: Duplication and divergence in actinopterygian fish. Journal of Molecular Evolution 56(3): 265-276.

    Merritt, TJS and JM Quattro. 2002. Negative charge correlates with neural expression in vertebrate aldolase isozymes. Journal of Molecular Evolution 55(6): 674-683.

    Merritt, TJS and JM Quattro. 2001. Evidence for a period of directional selection following gene duplication in a neurally-expressed locus of triosephosphate isomerase. Genetics 159(2): 689-697.

    Merritt, TJS, L Shi, MC Chase, MA Rex, RJ Etter, and JM Quattro. 1998. "Universal" cytochrome b primers facilitate intraspecific comparisons in Molluscan taxa. Molecular Marine Biology and Biotechnology 7: 7-11.

    Merritt, TJS, S LaForest, GD Prestwich, JM Quattro, and RG Vogt. 1998. Patterns of gene duplication in Lepidopteran pheromone binding proteins. Journal of Molecular Evolution 46: 272-276.