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Faculty Profiles

Guangdong Yang

Guangdong Yang 

Associate Professor

Chemistry and Biochemistry

Science, Engineering & Architecture

 

F-309, Science Building 

Sudbury Campus

 

705.675.1151 ext 2350705.675.1151 ext 2350

705.675.1151 ext 2350GYang2@laurentian.ca

Biography

07/2015-present,  Associate Professor,  Laurentian University, Sudbury, Canada

7/2012-06/2015,  Research Associate Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

3/2007-06/2012,  Research Assistant Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

9/2006-2/2007, Postdoctoral Fellow, Department of Biology, Lakehead University, Thunder Bay, Canada

10/2002-9/2006, Postdoctoral Fellow, Department of Physiology, University of Saskatchewan, Saskatoon, Canada

Education

PhD, Zhejiang University and Institute of Genetics and Development, Chinese Academy of Sciences, China

Research

I have a strong interest in gasotransmitter, biomolecular science, and signal transduction research. There are three areas of on-going research programs and interests funded by NSERC and HSFC, including: 1) Biological significance of H2S-mediated protein translational modification; 2) Roles of H2S in cell differentiation and organ development; 3) Regulation and function of H2S in vascular diseases, cancers and aging.


Job position (posted in April 16, 2018):

Two Masters, one PhD and one post-doctoral fellow position available immediately for studying the role of cystathionine gamma-lyase/H2S in cellular functions and cardiovascular diseases (Science. 322:587, 2008; EMBO Report. 15:792, 2014; Antioxid. Redox Signal. 23:630, 2015). The candidates with a strong academic and research background of molecular biology and biochemistry would be a definite asset. Applicants should email their interest and CV to gyang2@laurentian.ca.

Teaching

CHMI-5236EL-Molecular Biology of Eukaryotes (2016 winter, 2017 winter)

CHMI-5246EL-Selected Topics - Biochemistry (2016 winter and 2016 fall)

CHMI-4256EL-Biochemistry of Diseases (2016 fall, 2017 fall, 2018 fall)

CHMI-4207EL-Advanced Cellular Biochemistry (2017 winter, 2018 winter)

CHMI-3227EL-Experimenal Biochemistry (2018 winter)

CHMI-4615EL-Research Seminar (2018 fall and 2019 winter)     

Awards

  
  • New Investigator Award, Heart and Stroke Foundation of Canada (2009-2014)
  • Maureen Andrew New Investigator Award from Heart and Stroke Foundation of Ontario (2009), given to the highest rated Ontario New Investigator in the national competition who clearly demonstrates excellence in the area of cardiovascular or cerebrovascular research.
  • Heart and Stroke Foundation of Canada Research Fellowship (2006-2007)
  • Saskatchewan Health Research Foundation Post-Doctoral Fellowship (2004-2005)

Publications

Selective Publications (*, corresponding author)

1),    Yang G*, Ju Y, Fu M, Thomas M, Racine M, Batth S, Pei Y, Wang R, Wu L*. Cystathionine gamma-lyase/H2S system is essential for adipogenesis and fat mass formation in mice. BBA Molecular and Cell Biology of Lipids. 2017,1863:165-176.

2),    Bourque C, Zhang Y, Fu M, Racine M, Greasley A, Pei Y, Wu L, Wang R, Yang G*. H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells. Toxicol Appl Pharmacol. 2017,338:20-29.

3),    Ju Y, Fu M, Stokes E, Wu L, Yang G*. H₂S-mediated protein S-sulfhydration: a prediction for its formation and regulation. Molecules. 2017, 22:E1334.     

4),    Ju Y, Wu L, Yang G*. Thioredoxin 1 regulation of protein S-desulfhydration. Biochemistry and Biophysics Reports. 2016, 5:27-34.

5),    Ju Y, Untereiner A, Wu L, Yang G*. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. BBA - General Subjects. 2015, 1850:2293-303.

6),     Li S, Yang G*. H2S regulation of DNA methylation and mitochondrial DNA copy number. Antioxid. Redox Signal. 2015, 23:630-42.

7),     Zhao K, Li S, Wu L, Lai C, Yang G*. H2S represses androgen receptor transactivation by targeting at the second zinc-finger module.  J. Biol. Chem. 2014, 289:20824-35. 

8),     Zhao K, Ju Y, Li S, Zaid Al Taany, R Wang, Yang G*. Mediation of PARP and MEK1 in H2S-protected DNA damage repair response. EMBO report. 2014, 15:792-800. 

9),     Yang G*, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L, Wang R. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid. Redox Signal. 2013, 18:1906-19.

10),     Teng H, Wu B, Zhao K, Yang G, Wu L, Wang R. Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease. Proc Natl Acad Sci U S A. 2013, 110:12679-84.

11),     Yang G*, Li H, Tang G, Wu L, Zhao K, Cao Q, Xu C, Wang R*. Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in alpha5beta1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol. 2012, 52:677-88.

12),      Fu M, Zhang W, Wu L, Yang G, Wang R*. H2S metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A. 2012, 109:2943-8.

13),     Yang G*, Pei Y, Cao Q, Wang R*. MicroRNA-21 regulates cystathionine gamma-lyase expression in smooth muscle cells by targeting at specificity protein-1. J Cell Physiol 2012, 227:3192-200.

14),      Pei Y, Wu B, Cao Q, Wu L, Yang G*. H2S mediates the anti-survival role of sulforaphane on human prostate cancer cells. Toxicol Appl Pharmacol. 2011, 257:420-8. 

15),     Yang G*, Pei Y, Teng H, Cao Q, Wang R*. Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase expression during smooth muscle cell differentiation. J. Biol. Chem. 2011, 286:26450-60.

16),     Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, Snyder SH, Wang R*. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008, 322:587-90.

Please see the full publication list from Google scholar:  http://scholar.google.ca/citations?user=iyRAPdgAAAAJ&hl=en