Guangdong Yang

Guangdong Yang

Associate Professor

Department of Chemistry & Biochemistry
Science, Engineering & Architecture
F-309, Science Building Sudbury Campus

Biography

07/2015-present,  Associate Professor,  Laurentian University, Sudbury, Canada

7/2012-06/2015,  Research Associate Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

3/2007-06/2012,  Research Assistant Professor, School of Kinesiology, Lakehead University, Thunder Bay, Canada

9/2006-2/2007, Postdoctoral Fellow, Department of Biology, Lakehead University, Thunder Bay, Canada

10/2002-9/2006, Postdoctoral Fellow, Department of Physiology, University of Saskatchewan, Saskatoon, Canada

Education


Academic Appointments


On The Web


Research

I have a strong interest in gasotransmitter, biomolecular science, and signal transduction research. There are three areas of on-going research programs and interests funded by NSERC and HSFC, including: 1) Biological significance of H2S-mediated protein translational modification; 2) Roles of H2S in cell differentiation and organ development; 3) Regulation and function of H2S in vascular diseases, cancers and aging.


Job position (posted in April 16, 2018):

One PhD and one post-doctoral fellow position available immediately for studying the role of cystathionine gamma-lyase/H2S in cellular functions and cardiovascular diseases (Science. 322:587, 2008; EMBO Report. 15:792, 2014; Antioxid. Redox Signal. 23:630, 2015). The candidates with a strong academic and research background of molecular biology and biochemistry would be a definite asset. Applicants should email their interest and CV to gyang2@laurentian.ca.

Awards

  
  • New Investigator Award, Heart and Stroke Foundation of Canada (2009-2014)
  • Maureen Andrew New Investigator Award from Heart and Stroke Foundation of Ontario (2009), given to the highest rated Ontario New Investigator in the national competition who clearly demonstrates excellence in the area of cardiovascular or cerebrovascular research.
  • Heart and Stroke Foundation of Canada Research Fellowship (2006-2007)
  • Saskatchewan Health Research Foundation Post-Doctoral Fellowship (2004-2005)

Publications

Selective Publications since 2012 (*, corresponding author)

1),    Stokes E, Shuang T, Zhang Y,  Pei Y, Fu M, Guo B, Parissenti A, Wu L, Wang R, Yang G*. Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells. Life Sciences. 2018. In press.  

2),    Loiselle JJ, Yang G*, Wu L*. Hydrogen sulfide and hepatic lipid metabolism – a critical pairing for liver health. Br. J. Pharmacol. 2018. In press.

3),    Jin Z, Wang Z, Yang G*, Pei Y*. Diversity of hydrogen sulfide concentration in plant: A little spark to start a prairie fire. Sci. Bull. 2018. In press.

4),    Racine M, Shuang T, Zhang Y, Fu M, Pei Y, Wu L, Wang R, Yang G*. Reversal of Sp1 transactivation and TGF<beta>1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation. Toxicol Appl Pharmacol. 2018,356:25-35. 

5),    Yang G*, Ju Y, Fu M, Thomas M, Racine M, Batth S, Pei Y, Wang R, Wu L*. Cystathionine gamma-lyase/H2S system is essential for adipogenesis and fat mass formation in mice. BBA Molecular and Cell Biology of Lipids. 2017,1863:165-176.

6),    Bourque C, Zhang Y, Fu M, Racine M, Greasley A, Pei Y, Wu L, Wang R, Yang G*. H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells. Toxicol Appl Pharmacol. 2017,338:20-29.

7),    Ju Y, Fu M, Stokes E, Wu L, Yang G*. H₂S-mediated protein S-sulfhydration: a prediction for its formation and regulation. Molecules. 2017, 22:E1334.     

8),    Ju Y, Wu L, Yang G*. Thioredoxin 1 regulation of protein S-desulfhydration. Biochemistry and Biophysics Reports. 2016, 5:27-34.

9),    Ju Y, Untereiner A, Wu L, Yang G*. H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells. BBA - General Subjects. 2015, 1850:2293-303.

10),     Li S, Yang G*. H2S regulation of DNA methylation and mitochondrial DNA copy number. Antioxid. Redox Signal. 2015, 23:630-42.

11),    Ju Y, Fu M, Wu L, Yang G*. Strategies and tools for detection of protein S-nitrosylation and S-sulfhydration. Biochem Anal Biochem. 2015, 4: 224.

12),     Zhao K, Li S, Wu L, Lai C, Yang G*. H2S represses androgen receptor transactivation by targeting at the second zinc-finger module.  J. Biol. Chem. 2014, 289:20824-35. 

13),     Zhao K, Ju Y, Li S, Zaid Al Taany, R Wang*, Yang G*. Mediation of PARP and MEK1 in H2S-protected DNA damage repair response. EMBO report. 2014, 15:792-800. 

14),     Yang G*, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L, Wang R. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid. Redox Signal. 2013, 18:1906-19.

15),     Yang G*, Li H, Tang G, Wu L, Zhao K, Cao Q, Xu C, Wang R*. Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in alpha5beta1-integrin and matrix metalloproteinase-2 expression in smooth muscle cells. J Mol Cell Cardiol. 2012, 52:677-88.

16),     Yang G*, Pei Y, Cao Q, Wang R*. MicroRNA-21 regulates cystathionine gamma-lyase expression in smooth muscle cells by targeting at specificity protein-1. J Cell Physiol 2012, 227:3192-200.

Please see the full publication list from Google scholar:  http://scholar.google.ca/citations?user=iyRAPdgAAAAJ&hl=en